Trifluoroacetic acid → HCID 11570373, compound

Participants

Reaction Steps

To a solution of the intermediate from step F (128 mg) in CH2Cl2(2 mL) was added TFA (2 mL). After the reaction was stirred at room temperature for 30 minutes, it was concentrated in vacuo and azeotroped with toluene (3×). The resulting light yellow solid was dissolved in 1,4-dioxane and lyophilized overnight to afford the title compound as a white solid. 1H NMR (CD3OD, 500 MHz) 8.82 (d, J=1.8 Hz, 1H), 8.42 (s, 1H), 8.12 (d, J=8.5 Hz, 1H), 7.99 (d, J=8.0 Hz, 1H), 7.93 (t, J=7.3 Hz, 1H), 7.90 (d, J=1.6 Hz, 2H), 7.77 (t, J=7.5 Hz, 2H), 7.71 (d, J=8.3 Hz, 2H), 7.4 (s, 1H), 7.24 (d, J=8.3 Hz, 2H), 7.06 (s, 1H), 5.71 (q, J=6.8 Hz, 1H), 3.66 (t, J=6.9 Hz, 2H), 2.63 (t, J=7.1 Hz, 2H), 2.01 (d, J=6.8 Hz, 3H). LC-MS: 3.68 min; (M+H)=559.1.

Provenance & Evidence