Trifluoroacetic acid → HCID 57975539, compound

Participants

Reaction Steps

To a solution of the intermediate from step I (64 mg) in CH2Cl2(2 mL) was added TFA (2 mL). After the reaction was stirred at room temperature for 30 minutes it was concentrated in vacuo and azeotroped with toluene (3×). The resulting light yellow solid was dissolved in 1,4-dioxane and lyophilized overnight to afford the product as a white solid. 1H NMR (DMSO, 500 MHz) 8.8 (d, J=1.6 Hz, 1H), 8.45 (t, J=5.5 Hz, 1H), 8.38 (s, 1H), 7.94 (s, 2H), 7.92 (d, J=8.4 Hz, 2H), 7.72 (d, J=8.0 Hz, 2H), 7.58 (s, 1H), 7.45 (d, J=2.1 Hz, 1H), 7.37 (dd, J=2.3, 8.7 Hz, 1H), 7.28 (s, 1H), 7.2 (d, J=8.0 Hz, 2H), 5.8 (q, J=6.9 Hz, 1H), 3.95 (s, 3H), 3.41 (q, J=6.9 Hz, 2H), 2.45 (t, J=7.1 Hz, 2H), 1.93 (d, J=6.9 Hz, 3H). LC-MS: 3.53 min; (M+H)=588.9.

Provenance & Evidence