P-Anisidine → HCID 178469291, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of p-anisidine (2.7 g, 22 mmol) in methanol (50 mL) was added diethyl-acetylene dicarboxylate (3.74 g, 22 mmol). The resulting solution was heated at 55° C. for 1 hour. The reaction mixture was concentrated in vacuo. The residue was dissolved in phenyl ether (40 mL) and refluxed at 240° C. for 1 hour. The reaction mixture was cooled to room temperature, diluted with hexanes and filtered. A light brown solid was obtained. LC-MS: 1.39 min; (M+H)=248.1.

Provenance & Evidence