HCID 68682712, compound → HCID 68682186, compound

Participants

Reaction Steps

To 4-cyclopropylmethanesulfonyl-1-(pyrrolidine-1-carbonyl)-cyclohexanecarbonitrile (231 mg; 0.712 mmol) in 2 M ammonia in methanol solution (15 ml) under a nitrogen atmosphere was added Raney Nickel (approx. 1 ml of 50% aqueous slurry). The resulting mixture was agitated under an atmosphere of hydrogen (50 psi) on a Parr apparatus for 18 hours. The mixture was filtered through a catalyst filter and the catalyst washed extensively with MeOH (200 ml, added in portions). The filtrate was evaporated in vacuo to give the product as a pale green oil (241 mg). m/z=329 (M+H+).

Provenance & Evidence