HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 6-Chloro-imidazo[2,1-b]thiazole-5-sulfonic Acid [3-chloro-4-(naphthalen-2-ylsulfanyl)-phenyl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 6-Chloroimidazo(2,1-b)(1,3)thiazole-5-sulfonyl chloride | HCID 2799717 | — |
| Reactant | 3-Chloro-4-(napthalen-2-ylsulfanyl)-phenylamine | HCID 9861938 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 6-Chloro-imidazo[2,1-b]thiazole-5-sulfonic Acid [3-chloro-4-(naphthalen-2-ylsulfanyl)-phenyl]-amide | HCID 67255324 | 65% |
Reaction Steps
The title compound was prepared using the method of example 94, starting with 3-chloro-4-(naphthalen-2-ylsulfanyl)-phenylamine (92) (150 mg, 0.53 mmol), pyridine (Aldrich, 0.21 mL, 2.63 mmol) and 6-chloro-imidazo[2,1-b]thiazole-5-sulfonyl chloride (Maybridge, 149 mg, 0.58 mmol) in THF. 172 mg (65%) of 98 was obtained as a pale yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07626033B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-caf3ab08ace944c3aa49d41dbc97882f |
| Source note | uspto-grants-2009_12 |