2-Chloro-1-fluoro-4-nitrobenzene → 2-(2-Chloro-4-nitro-phenylsulfanyl)-5-trifluoromethyl-benzothiazole

HRID 1865522Notes

Reaction equation

HRID 1865522 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1F.[SH:12][C:13]1[S:14][C:15]2[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][C:16]=2[N:17]=1>>[Cl:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[S:12][C:13]1[S:14][C:15]2[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][C:16]=2[N:17]=1

Participants

3

Reactant 2

HCID 676882-Chloro-1-fluoro-4-nitrobenzeneHCID 1784190875-(trifluoromethyl)-1,3-benzothiazole-2-thiol

Product 1

HCID 221488372-(2-Chloro-4-nitro-phenylsulfanyl)-5-trifluoromethyl-benzothiazole

Procedure

2-(2-Chloro-4-nitro-phenylsulfanyl)-5-trifluoromethyl-benzothiazole (252) was prepared (92%) from 2-chloro-1-fluoro-4-nitrobenzene, obtained from Aldrich, and 5-trifluoromethyl-benzothiazol-2-thiol (239) in a similar manner as described in example 251.

Sources & evidence

ORD record
ord-350067737f98431d925f48564a4b87e0
Source dataset
uspto-grants-2009_12
Patent number
US07626033B2

Reaction notes

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