HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 22148876, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 1-(2,3-Dichloro-5-nitro-phenyl)-ethanone | HCID 22148738 | — |
| Reactant | 5-(trifluoromethyl)-1,3-benzothiazole-2-thiol | HCID 178419087 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 22148876 | HCID 22148876 | 87% |
Reaction Steps
The title compound was prepared using the method of example 258, starting with 5-trifluoromethyl-benzothiazole-2-thiol (239) (470 mg, 2.0 mmol), 1-(2,3-dichloro-5-nitro-phenyl)-ethanone (248) (466 mg, 2.0 mmol) and NaH (Aldrich, 60% suspension, 80 mg, 2.0 mmol) in DMF (20 mL). Compound 259 (750 mg, 87%) was obtained as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07626033B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-a9dc80071000430daa83db961687df94 |
| Source note | uspto-grants-2009_12 |