HuagongsheHuagongshe Chemistry Print Report · For research reference only
methyl L-prolinate hydrochloride → 1-[2-(Tert-butoxycarbonyl-methyl-amino)-3-methyl-butyryl]-pyrrolidine-2-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | methyl L-prolinate hydrochloride | HCID 2733200 | — |
| Reactant | Boc-N-methyl-L-valine | HCID 7010608 | — |
| Product | 1-[2-(Tert-butoxycarbonyl-methyl-amino)-3-methyl-butyryl]-pyrrolidine-2-carboxylic acid methyl ester | HCID 69018989 | 93.1% |
Reaction Steps
Using General Procedure I Method A, (2S)-(tert-Butoxycarbonyl-methyl-amino)-3-methyl-butyric acid (0.37 g, 1.6 mmol) is coupled to L-proline methyl ester hydrochloride (0.26 g, 1.6 mmol) to give 1-[2-(tert-butoxycarbonyl-methyl-amino)-3-methyl-butyryl]-pyrrolidine-2-carboxylic acid methyl ester (0.51 g, 93%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07626023B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-86d1825385964ec2814594859dc97a6b |
| Source note | uspto-grants-2009_12 |