Aluminium lithium hydride → HCID 86596610, compound

Participants

Reaction Steps

To a cooled solution (0° C., ice bath) of tert-butyl methyl[(1S)-2-methyl-1-(4-morpholinylcarbonyl)-2-phenylpropyl]carbamate (0.870 g, 2.32 mmol, from Reference Example 18) in anhydrous tetrahydrofuran (3.0 ml), 1.0M lithium aluminum hydride (5.8 ml, 5.8 mmol) in tetrahydrofuran is added dropwise over 30 minutes. The reaction mixture stirred at room temperature for 30 minutes and is quenched with 5% potassium hydrogen sulfate and stirred at room temperature for 15 minutes. The mixture is washed with ether (3 times). The organic layer is then collected and dried with sodium sulfate and concentrated in vacuo to give a colorless oil. The crude product is used without further purification. (0.940 g, 80%) MS [M+H] 292.2

Provenance & Evidence