HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiomorpholine → Sarsasapogenin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiomorpholine | HCID 67164 | — |
| Reactant | HCID 86619921 | HCID 86619921 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Sarsasapogenin | HCID 92095 | 139.7% |
Reaction Steps
10.3 g of thiomorpholine (27) was added dropwise to a mixture of 47.1 g of sarsasapogenin acrylate (28) and 200 g. of tetrahydrofuran. The mixture was stirred at room temperature for 3 hours, after which tetrahydrofuran was distilled off. Subsequent purification by silica gel column chromatography gave 56.2 g of sarsasapogenin [3-(thiomorpholino)propionate] (Quencher 7). Yield 98%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07629108B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-04d8465a273e4f0ca57607f174b981a5 |
| Source note | uspto-grants-2009_12 |