反应详情

The compound from Step 2 is suspended in dry ethanol and O-trimethylsilyl hydroxylamine (10 eq.) is added. The mixture is refluxed for 2 h, evaporated and the crude mixture purified by RP HPLC on a Phenominex column (250×20 mm) using a gradient of acetonitrile in water from 0 to 30% over 30 minutes at 10 mL/minute to yield the title compound.

1. temperatureThe mixture is refluxed for 2 h
2. customevaporated
3. customthe crude mixture purified by RP HPLC on a Phenominex column (250×20 mm)
4. customover 30 minutes