Diisopropanolamine → HCID 86637940, compound

Participants

Reaction Steps

Reaction of 2-chloro-3,5-dinitro-N-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]benzamide (17) (1.02 g) [For method of preparation see co-pending NZ Application No. 521851] with diisopropanolamine (0.8 g) as above gave 2-[bis(2-hydroxypropanyl)amino]-3,5-dinitro-N-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]benzamide (18) (1.29 g, 100%): as a yellow foam; 1H NMR [(CD3)2SO] δ 9.22 (br, 1 H), 8.66 (d, J=2.8 Hz, 1 H), 8.29 (d, J=2.8 Hz, 1 H), 4.99 (m, 1 H), 4.85 (br, 1 H), 4.62 (br, 1 H), 3.94 (m, 2 H), 3.77 (m, 2 H), 3.53 (m, 4 H), 3.26 (m, 2 H), 1.48 (m, 10 H), 0.98 (m, 6 H); 13C NMR δ 166.5, 147.8, 142.4, 138.2, 132.6, 128.8, 123.8, 98.1, 64.8, 63.5, 61.5, 60.1, 30.1, 25.0, 20.5, 20.2, 19.1. HRMS (FAB) Calcd. For C20H31N4O9 [M+H+] m/z 471.2091. Found; 471.2089.

Provenance & Evidence