Methanesulfonyl chloride → HCID 86610318, compound

HRID 1865807Notes

Reaction equation

[OH:1][CH:2]([CH3:33])[CH2:3][N:4]([CH2:29][CH:30]([OH:32])[CH3:31])[C:5]1[C:22]([N+:23]([O-:25])=[O:24])=[CH:21][C:20]([N+:26]([O-:28])=[O:27])=[CH:19][C:6]=1[C:7]([NH:9][CH2:10][CH2:11][O:12][CH:13]1[CH2:18][CH2:17][CH2:16][CH2:15][O:14]1)=[O:8].[CH3:34][S:35](Cl)(=[O:37])=[O:36]>>[CH3:34][S:35]([O:1][CH:2]([CH3:33])[CH2:3][N:4]([CH2:29][CH:30]([O:32][S:35]([CH3:34])(=[O:37])=[O:36])[CH3:31])[C:5]1[C:6]([C:7]([NH:9][CH2:10][CH2:11][O:12][CH:13]2[CH2:18][CH2:17][CH2:16][CH2:15][O:14]2)=[O:8])=[CH:19][C:20]([N+:26]([O-:28])=[O:27])=[CH:21][C:22]=1[N+:23]([O-:25])=[O:24])(=[O:37])=[O:36]

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 86637940HCID 86637940, compound

Product 1

HCID 86610318HCID 86610318, compoundYield 100%

Procedure

Reaction of 18 with MsCl as above gave 1-methyl-2-[{2-[(methylsulfonyl)oxy]propyl}-2,4-dinitro-6-({[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]amino}carbonyl)anilino]ethyl methanesulfonate (19) (2.52 g, 100%): as a yellow foam; which was used directly for the next step.

Sources & evidence

ORD record: ord-a781eb09de254ccfa38936334485ab8e
Source dataset: uspto-grants-2009_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07629332B2

Reaction notes

Loading…