Diethanolamine → HCID 86601655, compound

Participants

Reaction Steps

Reaction of 21 (1.45 g, 3.75 mmol) with diethanolamine (1.67 g) as above gave 2-[bis(2-hydroxyethyl)amino]-3,5-dinitro-N-[2-(tetrahydro-2H-pyran-2-yloxy)propyl]benzamide (22) (1.62 g, 95%): as a yellow foam; 1H NMR [(CD3)2SO] δ 8.96 (m, 1 H, CONH), 8.66 (d, J=2.8 Hz, 1 H, H-4), 8.31 (d, J=2.8 Hz, 1 H, H-6), 4.95 (m, 2 H), 4.56 (m, 1 H), 3.79-3.16 (m, 14 H), 1.80-1.45 (m, 8 H); 13C NMR δ 166.2, 148.1, 143.6, 139.3, 133.8, 128.9, 123.8, 98.5, 64.8, 61.7, 58.5, 54.6, 37.3, 30.6,29.2, 25.4, 19.6. HRMS (FAB) Calcd. For C19H29N4O6 [M+H+] m/z 457.1935. Found; 457.1939.

Provenance & Evidence