Formic Acid → HCID 57978002, compound

HRID 1865839Notes

Reaction equation

HRID 1865839 reaction equation
[Cl:1][C:2]1[N:3]=[N:4][C:5]([NH:22][NH2:23])=[C:6]([C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=2)[C:7]=1[C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=1.[CH:24](O)=O>O>[Cl:1][C:2]1[C:7]([C:8]2[CH:9]=[CH:10][C:11]([Cl:14])=[CH:12][CH:13]=2)=[C:6]([C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=2)[C:5]2[N:4]([CH:24]=[N:23][N:22]=2)[N:3]=1

Participants

4

Reactant 2

HCID 284Formic AcidHCID 57977997HCID 57977997, compound

Product 1

HCID 57978002HCID 57978002, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
120 °C

Procedure

To a round bottom flask was added 3-chloro-4,5-bis(4-chlorophenyl)-6-hydrazinylpyridazine (3.0 gm, 8.2 mmol) and formic acid (15 ml). The reaction was heated at 120° C. for 2 hrs. The reaction mixture was cooled to rt, poured into water (100 ml) and solid precipitated. The solid was collected by filtration to give product 6-chloro-7,8-bis(4-chlorophenyl)-[1,2,4]triazolo[4,3-b]pyridazine as a grey solid (2.8 gm, 91% yield). LCMS (M+H)=376.9; 1HNMR (CDCl3, 400 Hz): 9.16 (1H, s), 7.38-7.40 (4H, m), 7.37 (2H, d), 7.15 (2H, d).

Workup

  1. temperatureThe reaction mixture was cooled to rt
  2. customprecipitated
  3. filtrationThe solid was collected by filtration

Sources & evidence

ORD record
ord-24f2677698bf48babe2f1329b7915a5e
Source dataset
uspto-grants-2009_12
Patent number
US07629342B2

Reaction notes

Loading…