1,1'-Carbonyldiimidazole → HCID 86616960, compound

Participants

Reaction Steps

To a solution of 0.050 g (0.00016 mol) 6-(4-chloro-phenyl)-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid in 2 ml dimethylformamide was added at room temperature 0.055 g (0.00032 mol) 1,1′-carbonyl-diimidazole and the mixture was stirred at room temperature for 30 min. To the resulting mixture was added 0.072 g (0.00063 mol) 1-amino-2-cyclopropyl-propan-2-ol, and the mixture was stirred at room temperature for 17 hours. The resulting mixture was partitioned between 10% aqueous citric acid and ethyl acetate. The phases were separated and the organic phase was dried over magnesium sulfate and evaporated. The residue was purified by chromatography on silica gel using a gradient of heptane to ethyl acetate to yield 0.043 g (66% yield) of the title compound as slightly yellow oil. MS (ISP) (M+H+)=415.

Provenance & Evidence