2-Pyrimidinemethanol → HCID 86616979, compound

HRID 1865895Notes

Reaction equation

[OH:1][C@@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[NH:8][C:9]([C:11]1[CH:16]=[N:15][C:14](Br)=[C:13]([C:18]2[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=2)[N:12]=1)=[O:10].[N:25]1[CH:30]=[CH:29][CH:28]=[N:27][C:26]=1[CH2:31][OH:32]>>[OH:1][C@@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[NH:8][C:9]([C:11]1[CH:16]=[N:15][C:14]([O:32][CH2:31][C:26]2[N:27]=[CH:28][CH:29]=[CH:30][N:25]=2)=[C:13]([C:18]2[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=2)[N:12]=1)=[O:10]

Participants

Reactant 2

HCID 27630242-Pyrimidinemethanol

HCID 86616980HCID 86616980, compound

Product 1

HCID 86616979HCID 86616979, compound

Procedure

In analogy to example 55, however by starting from 5-bromo-6-(4-fluoro-phenyl)-pyrazine-2-carboxylic acid ((1R,2R)-2-hydroxy-cyclohexyl)-amide and pyrimidin-2-yl-methanol, the title compound was obtained as off-white solid. MS (ISP) (M+H+)=424.2.

Sources & evidence

ORD record: ord-8f27acf88c7a4d14b6d71f17c085c3b8
Source dataset: uspto-grants-2009_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07629346B2

Reaction notes

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