2-Pyrimidinemethanol → HCID 68837676, compound

HRID 1865896Notes

Reaction equation

[OH:1][C@@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[NH:8][C:9]([C:11]1[CH:16]=[N:15][C:14](Br)=[C:13]([C:18]2[CH:23]=[CH:22][C:21]([O:24][C:25]([F:28])([F:27])[F:26])=[CH:20][CH:19]=2)[N:12]=1)=[O:10].[N:29]1[CH:34]=[CH:33][CH:32]=[N:31][C:30]=1[CH2:35][OH:36]>>[OH:1][C@@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[NH:8][C:9]([C:11]1[CH:16]=[N:15][C:14]([O:36][CH2:35][C:30]2[N:31]=[CH:32][CH:33]=[CH:34][N:29]=2)=[C:13]([C:18]2[CH:23]=[CH:22][C:21]([O:24][C:25]([F:28])([F:27])[F:26])=[CH:20][CH:19]=2)[N:12]=1)=[O:10]

Participants

Reactant 2

HCID 27630242-Pyrimidinemethanol

HCID 86616966HCID 86616966, compound

Product 1

HCID 68837676HCID 68837676, compound

Procedure

In analogy to example 64, however by starting from 5-bromo-6-(4-trifluoromethoxy-phenyl)-pyrazine-2-carboxylic acid ((1R,2R)-2-hydroxy-cyclohexyl)-amide (example 21e) and pyrimidin-2-yl-methanol the title compound was obtained as an off-white solid. MS (ISP) (M+H+)=490.2.

Sources & evidence

ORD record: ord-658192e250f9481dbccf0afc4ac2f9eb
Source dataset: uspto-grants-2009_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07629346B2

Reaction notes

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