2-Pyrimidinemethanol → HCID 86616981, compound

HRID 1865897Notes

Reaction equation

[CH:1]1([C@@:4]([OH:24])([CH3:23])[CH2:5][NH:6][C:7]([C:9]2[CH:14]=[N:13][C:12](Br)=[C:11]([C:16]3[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=3)[N:10]=2)=[O:8])[CH2:3][CH2:2]1.[N:25]1[CH:30]=[CH:29][CH:28]=[N:27][C:26]=1[CH2:31][OH:32]>>[CH:1]1([C@@:4]([OH:24])([CH3:23])[CH2:5][NH:6][C:7]([C:9]2[CH:14]=[N:13][C:12]([O:32][CH2:31][C:26]3[N:27]=[CH:28][CH:29]=[CH:30][N:25]=3)=[C:11]([C:16]3[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=3)[N:10]=2)=[O:8])[CH2:3][CH2:2]1

Participants

Reactant 2

HCID 27630242-Pyrimidinemethanol

HCID 86616982HCID 86616982, compound

Product 1

HCID 86616981HCID 86616981, compound

Procedure

In analogy to example 26, however by starting from 5-bromo-6-(4-chloro-phenyl)-pyrazine-2-carboxylic acid ((S)-2-cyclopropyl-2-hydroxy-propyl)-amide and pyrimidin-2-yl-methanol the title compound was obtained as light yellow solid. MS (ISP) (M+H+)=440.2.

Sources & evidence

ORD record: ord-1c31985d6d464e72b7fe075f73d1b1e7
Source dataset: uspto-grants-2009_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07629346B2

Reaction notes

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