Water → HCID 57978103, compound

Participants

Reaction Steps

To a solution of 4,6-dichloro-2-methylsulfanyl-pyrimidine-5-carbaldehyde [Santilli, et al., J. Heterocycl. Chem. 1971, 8, 445-45] (4.0 g, 18.0 mmol) in CHCl3 (50 mL) was added 2,4-di-fluoroaniline (2.02 mL, 19.8 mmol) followed by Et3N (3.76 mL, 27 mmol, 1.5 eq). The reaction mixture turned yellow and was heated to reflux for 6 h, H2O (50 mL) was added and the layers were separated. The organic layer was evaporated to give 6.5 g (>100%) of the crude title compound which is pure enough to be used in the next step. LC MS (m/e)=316 (MH+).

Provenance & Evidence