HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Bromomethyl)pyridine → 1'-{[6-Chloro-1-(pyridin-3-ylmethyl)-1H-indol-3-yl]carbonyl}-1,2-dihydrospiro[indole-3,4'-piperidine]
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Bromomethyl)pyridine | HCID 245934 | — |
| Reactant | 1'-[(6-chloro-1H-indol-3-yl)carbonyl]-1,2-dihydrospiro[indole-3,4'-piperidine] | HCID 59657691 | — |
| Product | 1'-{[6-Chloro-1-(pyridin-3-ylmethyl)-1H-indol-3-yl]carbonyl}-1,2-dihydrospiro[indole-3,4'-piperidine] | HCID 59657565 | — |
Reaction Steps
Following the general procedure III as described above, the alkylation of 1′-[(6-chloro-1H-indol-3-yl)carbonyl]-1,2-dihydrospiro[indole-3,4′-piperidine] (prepared according to example 8) with commercially available 3-bromomethyl-pyridine gave the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07629353B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-1eedddf974a541b2897b0b04da8367ff |
| Source note | uspto-grants-2009_12 |