Tert-butyl 4-(2-chloroacetyl)piperazine-1-carboxylate → HCID 59657669, compound

HRID 1865932Notes

Reaction equation

HRID 1865932 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:11]([N:13]3[CH2:18][CH2:17][C:16]4([C:22]5[CH:23]=[CH:24][C:25]([F:27])=[CH:26][C:21]=5[C:20](=[O:28])[O:19]4)[CH2:15][CH2:14]3)=[O:12])=[CH:7][NH:8]2)=[CH:4][CH:3]=1.C(OC([N:36]1[CH2:41][CH2:40][N:39]([C:42](=[O:45])[CH2:43]Cl)[CH2:38][CH2:37]1)=O)(C)(C)C>>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:11]([N:13]3[CH2:18][CH2:17][C:16]4([C:22]5[CH:23]=[CH:24][C:25]([F:27])=[CH:26][C:21]=5[C:20](=[O:28])[O:19]4)[CH2:15][CH2:14]3)=[O:12])=[CH:7][N:8]2[CH2:43][C:42](=[O:45])[N:39]2[CH2:40][CH2:41][NH:36][CH2:37][CH2:38]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 15829156Tert-butyl 4-(2-chloroacetyl)piperazine-1-carboxylateHCID 596576231'-[(6-chloro-1H-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one

Product 1

HCID 59657669HCID 59657669, compound

Procedure

Following the general procedure V as described hereinabove, the alkylation of 1′-[(6-chloro-1H-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-1,4′-piperidin]-3-one (the preparation of which have been described in example 19) with commercially available 4-(2-Chloro-acetyl)-piperazine-1-carboxylic acid tert-butyl ester as electrophile, the title compound was obtained as a white solid after removal of the Boc protecting group under standard conditions (TFA/dichloromethane, room temperature).

Sources & evidence

ORD record
ord-fb424765c98644f58da105b040d5df78
Source dataset
uspto-grants-2009_12
Patent number
US07629353B2

Reaction notes

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