3,5-Difluorobenzoyl chloride → 5-Bromo-1'-[{6-chloro-1-(3,5-difluorobenzoyl)-1H-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one

HRID 1865956Notes

Reaction equation

HRID 1865956 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]2[C:8]3([O:26][C:27](=[O:28])[C:4]=2[CH:3]=1)[CH2:13][CH2:12][N:11]([C:14]([C:16]1[C:24]2[C:19](=[CH:20][C:21]([Cl:25])=[CH:22][CH:23]=2)[NH:18][CH:17]=1)=[O:15])[CH2:10][CH2:9]3.[F:29][C:30]1[CH:31]=[C:32]([CH:36]=[C:37]([F:39])[CH:38]=1)[C:33](Cl)=[O:34]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]2[C:8]3([O:26][C:27](=[O:28])[C:4]=2[CH:3]=1)[CH2:9][CH2:10][N:11]([C:14]([C:16]1[C:24]2[C:19](=[CH:20][C:21]([Cl:25])=[CH:22][CH:23]=2)[N:18]([C:33](=[O:34])[C:32]2[CH:31]=[C:30]([F:29])[CH:38]=[C:37]([F:39])[CH:36]=2)[CH:17]=1)=[O:15])[CH2:12][CH2:13]3

Participants

3

Reactant 2

HCID 1456003,5-Difluorobenzoyl chlorideHCID 596576195-bromo-1'-[(6-chloro-1H-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one

Product 1

HCID 596576455-Bromo-1'-[{6-chloro-1-(3,5-difluorobenzoyl)-1H-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one

Procedure

Following the general procedure VII as described above, the acylation of 5-bromo-1′-[(6-chloro-1H-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-1,4′-piperidin]-3-one with commercially available 3,5-difluorobenzoyl chloride gave the title compound.

Sources & evidence

ORD record
ord-4aae3ad97e724b43a9619c57de8401c2
Source dataset
uspto-grants-2009_12
Patent number
US07629353B2

Reaction notes

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