Biphenyl-2-boronic acid → HCID 59657512, compound

HRID 1865964Notes

Reaction equation

HRID 1865964 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:11]([N:13]3[CH2:18][CH2:17][C:16]4([C:22]5[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=5[C:20](=[O:27])[O:19]4)[CH2:15][CH2:14]3)=[O:12])=[CH:7][NH:8]2)=[CH:4][CH:3]=1.[C:28]1([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)[C:29](B(O)O)=[CH:30][CH:31]=[CH:32][CH:33]=1>>[C:28]1([C:37]2[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=2)[CH:29]=[CH:30][CH:31]=[CH:32][C:33]=1[N:8]1[C:9]2[C:5](=[CH:4][CH:3]=[C:2]([Cl:1])[CH:10]=2)[C:6]([C:11]([N:13]2[CH2:18][CH2:17][C:16]3([C:22]4[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=4[C:20](=[O:27])[O:19]3)[CH2:15][CH2:14]2)=[O:12])=[CH:7]1

Participants

3

Reactant 2

HCID 4589187Biphenyl-2-boronic acidHCID 596575991'-[(6-chloro-1H-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one

Product 1

HCID 59657512HCID 59657512, compound

Procedure

Following the general procedure VI as described above, the arylation of 1′-[(6-chloro-1H-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-1,4′-piperidin]-3-one (prepared according to example 16) with commercially available 2-biphenylboronic acid gave the title compound.

Sources & evidence

ORD record
ord-e40e9ae055c6446ab1ee31747de21321
Source dataset
uspto-grants-2009_12
Patent number
US07629353B2

Reaction notes

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