2-Chloro-5-(chloromethyl)pyridine → HCID 59657593, compound

HRID 1865970Notes

Reaction equation

HRID 1865970 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:11]([N:13]3[CH2:18][CH2:17][C:16]4([C:22]5[CH:23]=[CH:24][C:25]([F:27])=[CH:26][C:21]=5[C:20](=[O:28])[O:19]4)[CH2:15][CH2:14]3)=[O:12])=[CH:7][NH:8]2)=[CH:4][CH:3]=1.[Cl:29][C:30]1[CH:35]=[CH:34][C:33]([CH2:36]Cl)=[CH:32][N:31]=1>>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:11]([N:13]3[CH2:18][CH2:17][C:16]4([C:22]5[CH:23]=[CH:24][C:25]([F:27])=[CH:26][C:21]=5[C:20](=[O:28])[O:19]4)[CH2:15][CH2:14]3)=[O:12])=[CH:7][N:8]2[CH2:36][C:33]2[CH:32]=[N:31][C:30]([Cl:29])=[CH:35][CH:34]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 1554792-Chloro-5-(chloromethyl)pyridineHCID 596576231'-[(6-chloro-1H-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one

Product 1

HCID 59657593HCID 59657593, compound

Procedure

Following the general procedure III as described above, the alkylation of 1′-[(6-chloro-1H-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-1,4′-piperidin]-3-one (prepared according to example 19) with commercially available 2-chloro-5-chloromethylpyridine gave the title compound. ES-MS m/e (%): 524.1 (M+H+).

Sources & evidence

ORD record
ord-847cf5208bdf42e3a8807816304bfa9c
Source dataset
uspto-grants-2009_12
Patent number
US07629353B2

Reaction notes

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