HCID 20557702, compound → HCID 59657627, compound

HRID 1865971Notes

Reaction equation

HRID 1865971 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:11]([N:13]3[CH2:18][CH2:17][C:16]4([C:22]5[CH:23]=[CH:24][C:25]([F:27])=[CH:26][C:21]=5[C:20](=[O:28])[O:19]4)[CH2:15][CH2:14]3)=[O:12])=[CH:7][NH:8]2)=[CH:4][CH:3]=1.[Cl:29][C:30]1[N:31]=[N:32][C:33]([CH3:38])=[CH:34][C:35]=1[CH2:36]Cl>>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:11]([N:13]3[CH2:18][CH2:17][C:16]4([C:22]5[CH:23]=[CH:24][C:25]([F:27])=[CH:26][C:21]=5[C:20](=[O:28])[O:19]4)[CH2:15][CH2:14]3)=[O:12])=[CH:7][N:8]2[CH2:36][C:35]2[CH:34]=[C:33]([CH3:38])[N:32]=[N:31][C:30]=2[Cl:29])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 20557702HCID 20557702, compoundHCID 596576231'-[(6-chloro-1H-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one

Product 1

HCID 59657627HCID 59657627, compound

Procedure

Following the general procedure III as described above, the alkylation of 1′-[(6-chloro-1H-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-1,4′-piperidin]-3-one (prepared according to example 19 above) with 3-chloro-4-chloromethyl-6-methyl-pyridazine (prepared by U.S. Pat. No. 3,453,277) gave the title compound. ES-MS m/e (%): 539.1 (M+H+).

Workup

  1. customprepared by U.S

Sources & evidence

ORD record
ord-cb9357fa433a4778a6ccd13ab3de13b9
Source dataset
uspto-grants-2009_12
Patent number
US07629353B2

Reaction notes

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