1,4-Dibenzyl-2-(chloromethyl)piperazine → 1'-({6-Chloro-1-[(1,4-dibenzylpiperazin-2-yl)methyl]-1H-indol-3-yl}carbonyl)-5-fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one

Participants

Role	Name	HCID	Charge
Reactant	1,4-Dibenzyl-2-(chloromethyl)piperazine	HCID 10663119	—
Reactant	1'-[(6-chloro-1H-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one	HCID 59657623	—
Product	1'-({6-Chloro-1-[(1,4-dibenzylpiperazin-2-yl)methyl]-1H-indol-3-yl}carbonyl)-5-fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one	HCID 59657508	—

Reaction Steps

Following the general procedure III as described above, the alkylation of 1′-[(6-chloro-1H-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-1,4′-piperidin]-3-one (prepared according to example 19) with 1,4-dibenzyl-2-chloromethyl-piperazine (described in Journal of Medicinal Chemistry 1999, 42(9), 1587-1603) gave the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07629353B2
Source dataset	uspto-grants-2009_12
ORD ID	ord-9a7856f0b148487495ee1c875ed1b86b
Source note	uspto-grants-2009_12