Methanesulfonic acid 5-methyl-isoxazol-3-ylmethyl ester → 1'-({6-Chloro-1-[(5-methylisoxazol-3-yl)methyl]-1H-indol-3-yl}carbonyl)-5-fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one

Participants

Role	Name	HCID	Charge
Reactant	Methanesulfonic acid 5-methyl-isoxazol-3-ylmethyl ester	HCID 57476926	—
Reactant	1'-[(6-chloro-1H-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one	HCID 59657623	—
Product	1'-({6-Chloro-1-[(5-methylisoxazol-3-yl)methyl]-1H-indol-3-yl}carbonyl)-5-fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one	HCID 59657574	—

Reaction Steps

Following the general procedure III as described above, the alkylation of 1′-[(6-chloro-1H-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-1,4′-piperidin]-3-one (prepared according to example 19) with methanesulfonic acid 5-methyl-isoxazol-3-ylmethyl ester (described in WO 2004092172) gave the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07629353B2
Source dataset	uspto-grants-2009_12
ORD ID	ord-acbd91509b77453daee294cc38e3a851
Source note	uspto-grants-2009_12