HuagongsheHuagongshe Chemistry Print Report · For research reference only
1'-[(6-chloro-1H-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one → HCID 59657687, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1'-[(6-chloro-1H-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one | HCID 59657623 | — |
| Reactant | HCID 86610242 | HCID 86610242 | — |
| Product | HCID 59657687 | HCID 59657687 | — |
Reaction Steps
Following the general procedure III as described above, the alkylation of 1′-[(6-chloro-1H-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-1,4′-piperidin]-3-one (prepared according to example 19) with methanesulfonic acid 1,5-dimethyl-1H-pyrazol-3-ylmethyl ester (prepared by mesylation of commercially available methanesulfonic acid 1,5-dimethyl-1H-pyrazol-3-ylmethyl ester) gave the title compound. ES-MS m/e (%): 507.2 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07629353B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-7003ac7ba604498989f967f6c7d0d315 |
| Source note | uspto-grants-2009_12 |