HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Bromomethyl)-1-(methoxymethyl)cyclopropane → 1'-[(6-Chloro-1-{[1-(methoxymethyl)cyclopropyl]methyl}-1H-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Bromomethyl)-1-(methoxymethyl)cyclopropane | HCID 17937352 | — |
| Reactant | 1'-[(6-chloro-1H-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one | HCID 59657599 | — |
| Product | 1'-[(6-Chloro-1-{[1-(methoxymethyl)cyclopropyl]methyl}-1H-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one | HCID 59657560 | — |
Reaction Steps
Following the general procedure III as described above, the alkylation of 1′-[(6-chloro-1H-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-1,4′-piperidin]-3-one (prepared according to example 16 above) with 1-bromomethyl-1-methoxymethyl-cyclopropane (prepared as described in WO 2001032633) gave the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07629353B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-3169575e44844d74a6eaa424445ea274 |
| Source note | uspto-grants-2009_12 |