HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Piperidinecarbonyl chloride → 1'-{[6-Chloro-1-(piperidin-1-ylcarbonyl)-1H-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-1,4'-piperidine]
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Piperidinecarbonyl chloride | HCID 242085 | — |
| Reactant | (6-chloro-1H-indol-3-yl)-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanone | HCID 15951937 | — |
| Product | 1'-{[6-Chloro-1-(piperidin-1-ylcarbonyl)-1H-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-1,4'-piperidine] | HCID 59657655 | — |
Reaction Steps
Following the general procedure V as described hereinabove, the alkylation of 1′-[(6-chloro-1H-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-1,4′-piperidine] (the preparation of which have been described in example 69) with commercially available piperidine-1-carbonyl chloride as electrophile, the title compound was obtained as a white powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07629353B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-958152954d7345e986a8b117133dc55f |
| Source note | uspto-grants-2009_12 |