Tert-butyl 4-(2-chloroacetyl)piperazine-1-carboxylate → HCID 59657620, compound

HRID 1866006Notes

Reaction equation

HRID 1866006 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:11]([N:13]3[CH2:18][CH2:17][C:16]4([C:22]5[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=5[CH2:20][O:19]4)[CH2:15][CH2:14]3)=[O:12])=[CH:7][NH:8]2)=[CH:4][CH:3]=1.C(OC([N:34]1[CH2:39][CH2:38][N:37]([C:40](=[O:43])[CH2:41]Cl)[CH2:36][CH2:35]1)=O)(C)(C)C>>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:11]([N:13]3[CH2:18][CH2:17][C:16]4([C:22]5[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=5[CH2:20][O:19]4)[CH2:15][CH2:14]3)=[O:12])=[CH:7][N:8]2[CH2:41][C:40](=[O:43])[N:37]2[CH2:38][CH2:39][NH:34][CH2:35][CH2:36]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 15829156Tert-butyl 4-(2-chloroacetyl)piperazine-1-carboxylateHCID 15951937(6-chloro-1H-indol-3-yl)-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanone

Product 1

HCID 59657620HCID 59657620, compound

Procedure

Following the general procedure V as described hereinabove, the alkylation of 1′-[(6-chloro-1H-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-1,4′-piperidine] (the preparation of which have been described in example 69) with commercially available 4-(2-chloro-acetyl)-piperazine-1-carboxylic acid tert-butyl ester as electrophile, the title compound was obtained as a white solid after removal of the Boc protecting group under standard conditions (TFA/dichloromethane, room temperature).

Sources & evidence

ORD record
ord-19eff64b4228452180f03a6787331926
Source dataset
uspto-grants-2009_12
Patent number
US07629353B2

Reaction notes

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