Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1866011Generated: November 4, 2026

1,4-Dibenzyl-2-(chloromethyl)piperazine → HCID 59657554, compound

https://huagongshe.com/reaction/1866011

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,4-Dibenzyl-2-(chloromethyl)piperazineHCID 10663119—
Reactant(6-chloro-1H-indol-3-yl)-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanoneHCID 15951937—
ProductHCID 59657554HCID 59657554—

Reaction Steps

Following the general procedure III as described above, the alkylation of 1′-[(6-chloro-1H-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-1,4′-piperidine] (prepared according to example 69 above) with 1,4-dibenzyl-2-chloromethyl-piperazine (described in Journal of Medicinal Chemistry (1999), 42(9), 1587-1603) gave the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07629353B2
Source datasetuspto-grants-2009_12
ORD IDord-955ba10dfa27459db574e7f5857ae202
Source noteuspto-grants-2009_12