Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(6-chloro-1H-indol-3-yl)-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanone → 1'-{[6-Chloro-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-1,4'-piperidine]
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (6-chloro-1H-indol-3-yl)-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanone | HCID 15951937 | — |
| 반응물 | 2-(Tetrahydro-2H-pyran-4-yl)ethyl methanesulfonate | HCID 22273083 | — |
| 생성물 | 1'-{[6-Chloro-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-1,4'-piperidine] | HCID 59657638 | 55% |
반응 단계
Following the general procedure III as described above, the alkylation of 1′-[(6-chloro-1H-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-1,4′-piperidine] (prepared according to example 69) with commercially available methanesulfonic acid 2-(tetrahydro-pyran-4-yl)-ethyl ester (described in US 2004220214) gave the title compound in 55% yield. ES-MS m/e (%): 465.2 (M+H+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07629353B2 |
| 출처 데이터셋 | uspto-grants-2009_12 |
| ORD ID | ord-e3911729c3df4f44afb07e1276c969a8 |
| 출처 메모 | uspto-grants-2009_12 |