HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-chloro-1H-indole-3-carboxylic acid → 5-Bromo-1'-[(6-chloro-1H-indol-3-yl)carbonyl]spiro[indole-3,4'-piperidin]-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-chloro-1H-indole-3-carboxylic acid | HCID 18453235 | — |
| Reactant | 5-Bromospiro[indoline-3,4'-piperidin]-2-one | HCID 59657582 | — |
| Product | 5-Bromo-1'-[(6-chloro-1H-indol-3-yl)carbonyl]spiro[indole-3,4'-piperidin]-2(1H)-one | HCID 59657719 | — |
Reaction Steps
Following the general procedure I as described above, the acylation of 5-bromospiro[indole-3,4′-piperidin]-2(1H)-one with 6-chloro-1H-indole-3-carboxylic acid (preparation described in example 5 above), gave the title compound. ES-MS m/e (%): 458.3 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07629353B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-0699be0e88d64f328e475e0442963fd2 |
| Source note | uspto-grants-2009_12 |