Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
8-Fluoro-2-tetralone → HCID 22708789, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 8-Fluoro-2-tetralone | HCID 4137901 | — |
| 반응물 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 반응물 | N-(2-nitrobenzenesulfonyl)-N-(2-pyridinylmethyl)-1,4-benzenedimethanamine | HCID 22708748 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | HCID 22708789 | HCID 22708789 | 92% |
반응 단계
Following General Procedure B: Reaction of 8-fluoro-2-tetralone (159 mg, 0.97 mmol), N-(2-nitrobenzenesulfonyl)-N-(2-pyridinylmethyl)-1,4-benzenedimethanamine (400 mg, 0.97 mmol) and NaBH(OAc)3 (411 mg, 1.9 mmol) in a mixture of CH2Cl2 (10 mL) and acetic acid (0.2 mL) for 18 hours followed by purification of the crude material by column chromatography on silica gel (CHCl3/MeOH/NH4OH 20:2:1) afforded the title compound (500 mg, 92%) as a yellow foam.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07629337B2 |
| 출처 데이터셋 | uspto-grants-2009_12 |
| ORD ID | ord-a5a036f8a417481abb4905cc6bd6bd26 |
| 출처 메모 | uspto-grants-2009_12 |