Hydrochloric Acid → HCID 57977444, compound

Participants

Reaction Conditions

Reaction Steps

At room temperature, 0.2 g (0.55 mmol) of methyl 7-(1,2-dimethylpropylamino)-5-methoxy-6-(3-methylthiophen-2-yl)pyrazolo[1,5-α]pyrimidine-3-carboxylate was mixed with a mixture of 5 ml of 1,4-dioxane and 2.5 ml (2.5 mmol) of a 1 N sodium hydroxide solution. The mixture was then stirred at 22° C. for 16 hours. 5 ml of water and 3 ml of 1 N hydrochloric acid were added to the reaction mixture. The precipitate formed was filtered off, washed with water and dried. This gave 0.2 g of 7-(1,2-dimethylpropylamino)-5-methoxy-6-(3-methylthiophen-2-yl)pyrazolo[1,5-α]-pyrimidine-3-carboxylic acid (logPs=3.65; content according to HPLC: 96%).

Provenance & Evidence