HCID 13926583, compound → HCID 178433980, compound

HRID 1866092Notes

Reaction equation

HRID 1866092 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH:9]([C:14]([O:16]C)=O)[C:10]([O:12]C)=O.[CH3:18][C:19]1[O:23][C:22]([C:24]2[CH:28]=[N:27][NH:26][C:25]=2[NH2:29])=[N:21][N:20]=1>>[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:10]([OH:12])=[N:29][C:25]2[N:26]([N:27]=[CH:28][C:24]=2[C:22]2[O:23][C:19]([CH3:18])=[N:20][N:21]=2)[C:14]=1[OH:16]

Participants

3

Reactant 2

HCID 13926583HCID 13926583, compoundHCID 69073284HCID 69073284, compound

Product 1

HCID 178433980HCID 178433980, compound

Conditions

Temperature
185 °C

Procedure

0.789 g of dimethyl 2-chloro-4-fluorophenylmalonate and 0.79 ml of tributyalmine were added to 0.5 g of the 4-(5-methyl-[1,3,4]oxadiazol-2-yl)-2H-pyrazol-3-ylamine obtained under Ac), and the mixture was stirred at 185° C. for 3 h. Concentration gave a glass-like substance.

Workup

  1. customobtained under Ac), and the mixture
  2. concentrationConcentration
  3. customgave a glass-like substance

Sources & evidence

ORD record
ord-5ad5293bd35b4208931c8055ea27b645
Source dataset
uspto-grants-2009_12
Patent number
US07629294B2

Reaction notes

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