4-(3-Amino-2-hydroxypropoxy)-1,3-dihydrobenzimidazol-2-one → N-[4-[[4-[4-[[2-hydroxy-3-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]propyl]amino]piperidin-1-yl]phenyl]sulfamoyl]phenyl]acetamide

HRID 186619Notes

Reaction equation

HRID 186619 reaction equation
[O:1]=[C:2]1[CH2:3][CH2:4][N:5]([c:8]2[cH:9][cH:10][c:11]([NH:14][S:15](=[O:16])(=[O:17])[c:18]3[cH:19][cH:20][c:21]([NH:24][C:25]([CH3:26])=[O:27])[cH:22][cH:23]3)[cH:12][cH:13]2)[CH2:6][CH2:7]1.[OH:28][CH:29]([CH2:30][O:31][c:32]1[cH:33][cH:34][cH:35][c:36]2[nH:37][c:38](=[O:41])[nH:39][c:40]12)[CH2:42][NH2:43]>>[CH:2]1([NH:43][CH2:42][CH:29]([OH:28])[CH2:30][O:31][c:32]2[cH:33][cH:34][cH:35][c:36]3[nH:37][c:38](=[O:41])[nH:39][c:40]23)[CH2:3][CH2:4][N:5]([c:8]2[cH:9][cH:10][c:11]([NH:14][S:15](=[O:16])(=[O:17])[c:18]3[cH:19][cH:20][c:21]([NH:24][C:25]([CH3:26])=[O:27])[cH:22][cH:23]3)[cH:12][cH:13]2)[CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 158962374-(3-Amino-2-hydroxypropoxy)-1,3-dihydrobenzimidazol-2-oneHCID 22220411N-{4-[4-(4-Oxo-piperidin-1-yl)-phenylsulfamoyl]-phenyl}-acetamide

Product 1

HCID 22220333N-[4-[[4-[4-[[2-hydroxy-3-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]propyl]amino]piperidin-1-yl]phenyl]sulfamoyl]phenyl]acetamide

Sources & evidence

ORD record
ord-07a9c0e324db47a0a685381143eb005f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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