HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 6-cyano-1H-indole-2-carboxylate → 6-Cyano-1H-indole-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 6-cyano-1H-indole-2-carboxylate | HCID 4715002 | — |
| Reactant | Ammonia methanol | HCID 21705897 | — |
| Product | 6-Cyano-1H-indole-2-carboxamide | HCID 67095753 | 88.6% |
Reaction Steps
Treat 6-cyano-1H-indole-2-carboxylic acid ethyl ester 5a (m=0, 1.0 g, 4.67 mmol) with 7 N NH3/MeOH as described in General Procedure IV to afford the title compound as an ivory colored solid (766 mg, 88.6%), mp 241-242° C.; 1H NMR (DMSO-d6) δ 11.5 (brs, 1H), 8.16 (brs, 1H), 7.83 (s, 1H), 7.80 (d, 1H, J=8.0 Hz), 7.58 (brs, 1H), 7.35 (d, 1H, J=8.0 Hz), 7.23 (s, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07629376B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-b2c8717aea4e4bcfa124d11e94451437 |
| Source note | uspto-grants-2009_12 |