HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → 1-methyl-1H-indole-5-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | HCID 76850762 | HCID 76850762 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | 1-methyl-1H-indole-5-carbaldehyde | HCID 7537534 | — |
Reaction Steps
Treat 5-formyl-3-phenylsulfanyl-1H-indole-2-carboxylic acid amide 13 (m=0, R3=Ph; 400 mg, 1.35 mmol) with MeI (101 μl) as described in General Procedure XIV to provide the 5-formyl-1-methylindole the title compound 14 (280 mg, 67%), Rf (5% MeOH/CH2Cl2)=0.75.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07629376B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-bdcc0ee743f347458849c26cea8598ab |
| Source note | uspto-grants-2009_12 |