HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dioxa-8-azaspiro(4.5)decane → HCID 11582613, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dioxa-8-azaspiro(4.5)decane | HCID 67435 | — |
| Reactant | HCID 76850762 | HCID 76850762 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 11582613 | HCID 11582613 | — |
Reaction Steps
Treat 5-formyl-3-phenylsulfanyl-1H-indole-2-carboxylic acid amide 13 (m=0, R3=Ph) (80 mg, 0.27 mmol) with 1,4-dioxa-8-aza-spiro[4,5]decane (71.6 mg, 0.50 mmol) as described in General Procedure X to afford Iz (51.0 mg, 44.7%) as a tan solid, tlc Rf=0.35 (10% MeOH/CH2Cl2-0.20% Et3N), m/z obs=424 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07629376B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-36e119b4108d41dbb4960a4a0a3f1cda |
| Source note | uspto-grants-2009_12 |