Ethanol → Desloratadine

HRID 186624Notes

Reaction equation

HRID 186624 reaction equation
[CH3:30][CH2:31][OH:32].[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:27]1)[CH2:7][CH2:8][c:9]1[c:10]([n:11][cH:12][cH:13][cH:14]1)[C:15]2=[C:16]1[CH2:17][CH2:18][N:19]([C:22]([O:23][CH2:24][CH3:25])=[O:26])[CH2:20][CH2:21]1.[K+:29].[OH-:28]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:27]1)[CH2:7][CH2:8][c:9]1[c:10]([n:11][cH:12][cH:13][cH:14]1)[C:15]2=[C:16]1[CH2:17][CH2:18][NH:19][CH2:20][CH2:21]1

Participants

5

Reactant 4

HCID 702EthanolHCID 813Potassium CationHCID 961HydroxideHCID 3957Loratadine

Product 1

HCID 124087Desloratadine

Sources & evidence

ORD record
ord-3980bd17c07f4c0cb2cd53f2d1ec6dc4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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