HuagongsheHuagongshe Chemistry Print Report · For research reference only
Alanine methyl ester hydrochloride → (S)-2-[(7-Isopropoxy-1-chloro-4-hydroxy-isoquinoline-3-carbonyl)-amino]-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Alanine methyl ester hydrochloride | HCID 2733257 | — |
| Reactant | 1-Chloro-4-hydroxy-7-isopropoxy-isoquinoline-3-carboxylic acid | HCID 53870439 | — |
| Product | (S)-2-[(7-Isopropoxy-1-chloro-4-hydroxy-isoquinoline-3-carbonyl)-amino]-propionic acid | HCID 86761022 | — |
Reaction Steps
Analogously to Example A-56, 0.040 g of 7-isopropoxy-1-chloro-4-hydroxy-isoquinoline-3-carboxylic acid were allowed to react with 0.020 g of L-Alanine methyl ester hydrochloride to give, after hydrolysis of the intermediate ester, 0.047 g of a white solid: MS-(−)-ion, M−1=353.1 amu.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07629357B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-c61ecec729a04000bfda20cbd4a8d201 |
| Source note | uspto-grants-2009_12 |