L-Alanine → HCID 57473362, compound

HRID 1866271Notes

Reaction equation

HRID 1866271 reaction equation
C(O[C:6]([C:8]1[N:9]=[CH:10][C:11]2[C:16]([C:17]=1[OH:18])=[CH:15][CH:14]=[C:13]([O:19][C:20]1[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][CH:21]=1)[CH:12]=2)=[O:7])CCC.[NH2:27][C@H:28]([C:30]([OH:32])=[O:31])[CH3:29]>>[Cl:26][C:23]1[CH:24]=[CH:25][C:20]([O:19][C:13]2[CH:12]=[C:11]3[C:16]([C:17]([OH:18])=[C:8]([C:6]([NH:27][C@@H:28]([CH3:29])[C:30]([OH:32])=[O:31])=[O:7])[N:9]=[CH:10]3)=[CH:15][CH:14]=2)=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 5950L-AlanineHCID 66712772HCID 66712772, compound

Product 1

HCID 57473362HCID 57473362, compound

Procedure

Prepared in analogy to Example A-50 by reacting 7-(4-Chloro-phenoxy)-4-hydroxy-isoquinoline-3-carboxylic acid butyl ester (compound of example A-60 a) with L-alanine in a microwave reactor for 20 min at 130° C. MS-(−)-ion: M−1=385.1.

Workup

  1. customfor 20 min
  2. customat 130° C

Sources & evidence

ORD record
ord-d89ca40384d24cf2bbd84603ce4094ca
Source dataset
uspto-grants-2009_12
Patent number
US07629357B2

Reaction notes

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