2-Naphthalenethiol → HCID 11165602, compound

HRID 1866424Notes

Reaction equation

HRID 1866424 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([OH:12])=[C:4]([C:13]([NH:15][CH2:16][C:17]([OH:19])=[O:18])=[O:14])[N:3]=1.[CH:20]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH:23]=[CH:22][C:21]=1[SH:30]>>[OH:12][C:5]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:2]([S:30][C:21]2[CH:22]=[CH:23][C:24]3[C:29](=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH:20]=2)=[N:3][C:4]=1[C:13]([NH:15][CH2:16][C:17]([OH:19])=[O:18])=[O:14]

Participants

3

Reactant 2

HCID 70582-NaphthalenethiolHCID 6914666FG-2216

Product 1

HCID 11165602HCID 11165602, compound

Procedure

The title compound was prepared from [(1-chloro-4-hydroxy-isoquinoline-3-carbonyl)-amino]-acetic acid (U.S. Pat. No. 6,093,730) and 2-napthalenethiol under conditions analogous to Example D-110. The final product was purified by triturating the crude product twice with methanol and twice with dichloromethane; MS (+) m/z 405.08 (M+1).

Workup

  1. customThe final product was purified
  2. customby triturating the crude product twice with methanol

Sources & evidence

ORD record
ord-ce7b379c2e554195bdc8bf23808ca77e
Source dataset
uspto-grants-2009_12
Patent number
US07629357B2

Reaction notes

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