p-Bromobenzenesulfonyl chloride → 4-[(4-Bromobenzene)sulfonyl]morpholine

Participants

Reaction Steps

To a solution of 4-bromobenzenesulfonylchloride (2.555 g, 10 mmol) in CH2Cl2 (40 mL) was added a solution of triethylamine (1.53 mL, 11 mmol) and morpholine (0.96 mL, 11 mmol) at room temperature under argon atmosphere. The solution was stirred for 2 h and the mixture was purified by flash chromatography eluted with mixed solvent of EtOAc: hexanes (1:2, v/v) to provide 3.028 g (9.89 mmol, yield 98.9%) of N-(4-bromobenzenesulfonyl)morpholine as a white solid.

Provenance & Evidence