HCID 57978218, compound → HCID 57978258, compound

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Reaction Steps

A suspension of methyl 3-[(2R)-2-({(2R)-2-[4-(benzyloxy)-3-(hydroxymethyl)phenyl]-2-hydroxyethyl}amino)propyl]benzoate (Preparation 61) (6.83 g, 15.2 mmol) and 10% palladium on carbon (683 mg) in ethanol (100 ml) was stirred under an atmosphere of hydrogen (60 psi) at room temperature for 18 hours. The catalyst was filtered off through arbocel and the filtrate concentrated in vacuo. The residue was purified by flash column chromatography on silica gel eluting with dichloromethane:methanol:880 ammonia (95:5:0.5 changing to 90:10:1, by volume) to give the title compound as a pale yellow gum (5.12 g). 1H NMR (400 MHz, CD3OD): δ=7.85-7.83 (1H, m), 7.79 (1H, s), 7.36-7.35 (2H, m), 7.20 (1H, s), 7.02-6.99 (1H, dd), 6.68-6.65 (1H, d), 4.61-4.58 (1H, m), 4.60 (2H, s), 3.90 (3H, s), 2.97-2.87 (2H, m), 2.80-2.62 (3H, m), 1.08-1.07 (3H, d) ppm. LRMS (electrospray): m/z [M+H]+ 360, [M+Na]+ 382, [M−H]− 358.

Provenance & Evidence