Hydrochloric Acid → HCID 69025476, compound

Participants

Reaction Steps

A mixture of methyl {3-[2-({(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino)-2-methylpropyl]phenyl}acetate (preparation 153), (5 g, 10 mmol) and lithium hydroxide (1M in water, 30 mL, 30 mmol) in tetrahydrofuran (50 mL) was stirred for 48 hours at room temperature. The reaction mixture was then acidified with 1M hydrochloric acid (30 mL), concentrated in vacuo, and the residue was triturated with water and azeotroped (×3) with methanol to afford the title compound as a white solid in 84% yield, 4.1 g.

Provenance & Evidence