1-Pyrrolidinepropanamine → HCID 57978214, compound

HRID 1866560Notes

Reaction equation

[Si:1]([O:8][C@H:9]([C:26]1[CH:31]=[CH:30][C:29]([OH:32])=[C:28]([CH2:33][OH:34])[CH:27]=1)[CH2:10][NH:11][C:12]([CH3:25])([CH3:24])[CH2:13][C:14]1[CH:15]=[C:16]([CH2:20][C:21](O)=[O:22])[CH:17]=[CH:18][CH:19]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[N:35]1([CH2:40][CH2:41][CH2:42][NH2:43])[CH2:39][CH2:38][CH2:37][CH2:36]1>>[Si:1]([O:8][C@H:9]([C:26]1[CH:31]=[CH:30][C:29]([OH:32])=[C:28]([CH2:33][OH:34])[CH:27]=1)[CH2:10][NH:11][C:12]([CH3:25])([CH3:24])[CH2:13][C:14]1[CH:15]=[C:16]([CH2:20][C:21]([NH:43][CH2:42][CH2:41][CH2:40][N:35]2[CH2:39][CH2:38][CH2:37][CH2:36]2)=[O:22])[CH:17]=[CH:18][CH:19]=1)([C:4]([CH3:7])([CH3:5])[CH3:6])([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 316701-Pyrrolidinepropanamine

HCID 69025476HCID 69025476, compound

Product 1

HCID 57978214HCID 57978214, compoundYield 16%

Procedure

The title compound was prepared from {3-[2-({(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino)-2-methylpropyl]phenyl}acetic acid (preparation 154) and 1-pyrrolidinepropanamine, using a similar method to that of preparation 38, in 16% yield.

Workup

customof preparation 38

Sources & evidence

ORD record: ord-d9297acda55347cfb6603e42a9bf724c
Source dataset: uspto-grants-2009_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07629358B2

Reaction notes

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